The Most Cancer Suppressing Compounds Are Found In These Veggies


Published:

New research has linked a compound found in Brussels sprouts, broccoli, and other cruciferous vegetables to one of the body’s most potent tumor-suppressing genes.

Experts estimate that there can be up to 100 times more enzymes in sprouts than uncooked fruits and vegetables. Enzymes are special types of proteins that act as catalysts for all your body’s functions. Extracting more vitamins, minerals, amino acids, and essential fatty acids from the foods you eat ensures that your body has the nutritional building blocks of life to ensure every process works more effectively.

The discovery that sulforaphane is a potent antibiotic was reported in 2002 at Johns Hopkins. Broccoli sprouts have a much higher concentration of sulforaphane than mature heads. Sulforaphane appears to trigger cells in the body, including in the gastrointestinal tract, to produce enzymes that protect against oxygen radicals, DNA-damaging chemicals, and inflammation that benefit osteoarthritis and cancer.

Sprouts are alkalizing to your body. Many illnesses including cancer have been linked to excess acidity in the body. Growth of cancer cells are initiated by a lack of oxygen and these cells, along with viruses and bacteria, cannot live in an alkaline and oxygen rich environment. Broccoli sprouts are especially effective at preventing gastritis, ulcers, stomach cancer and even allergy and asthma.

The study says that the compound, called I3C, is involved in a complex chemical chain reaction that frees the tumor suppressor to do its job. The research also highlights the chemical warfare that goes on inside the body as it struggles to prevent tumors from developing even as tumors themselves fight to grow and spread.

The research comes out of the lab of Pier Paolo Pandolfi at Beth Israel Deaconess Medical Center’s Cancer Center and Cancer Research Institute. Pandolfi, the Victor J. Aresty Professor of Medicine at Harvard Medical School, headed a team that explored the function of a cancer-suppressing gene called PTEN, which encodes a protein that controls cell growth. Pandolfi called PTEN "one of the most important tumor suppressors in the history of cancer genetics.

“The study’s really exciting,” he said. “I’ve been bombarded by journalists—because of the broccoli connection, let’s be honest. Forget what you think about the science, the fact that [we found] something that your grandma would say [is] good for you, it’s appealing.”

PTEN is regularly targeted by cancers, which seek to delete, mutate, or otherwise inactivate it. Pandolfi and his team, representing institutions in the U.S., Taiwan, China, Italy, Australia, and India, set out to discover how. Using human cells and mice bred to develop cancer, the researchers found that an enzyme known to promote cancer growth, called WWP1, played an important role in interfering with PTEN function.

The researchers analyzed and created a computer model of WWP1’s physical structure, enabling them to search chemical libraries for a molecule that might bind to it and block its function. They discovered that a naturally occurring compound found in cruciferous vegetables—indole-3-carbinol, or I3C—did the trick, neutralizing the enzyme and restoring PTEN’s tumor-suppressing powers in lab mice engineered to develop prostate cancer.

The work, published in the journal Science and supported by the National Institutes of Health may provide a way to help people suffering from a genetic PTEN deficiency, which in addition to making them prone to developing cancer also causes developmental defects that can result in intellectual disability or psychiatric illness.

PTEN is also known to affect health more broadly. Mice that produce surplus PTEN develop smaller than normal bodies—likely because of PTEN’s restraint on surplus cell division—but are metabolically healthier than normal mice and live longer.

The PTEN-protecting compound, I3C, was already known to science and thought to have anti-cancer properties, though its precise mechanism was a mystery. It occurs naturally in the cruciferous vegetables that include broccoli, Brussels sprouts, arugula, cabbage, kale, and cauliflower. That group has been investigated in the past for its cancer-fighting properties, according to the National Cancer Institute, with promising results in animal studies, but mixed results in humans.

But for anyone encouraged by the results who wants to embark on a broccoli-eating binge, Pandolfi said there’s a chore ahead. The doses effective in laboratory mice would be the human equivalent of eating more than six pounds of broccoli daily.

From a practical standpoint, that means the most likely approach would be to develop a pill form, Pandolfi said. I3C seems to be well-tolerated by humans and is actually on the market based on anti-cancer properties exhibited in preliminary studies. Its targets aren’t limited to WWP1, so additional work is needed to investigate appropriate doses and unintended effects of I3C supplements, Pandolfi said.

An alternative, albeit one that will take time, would be to develop a more narrowly targeted molecule based on I3C’s structure that zeroes in on WWP1. Pandolfi said his team’s future research will likely move in those directions.

This article was republished from Prevent Disease.

See also:
Sprouting: How To Grow Sprouts At Home For Low Cost Nutritious Meals
Spring Vegetables: Fast, Fresh Food For Body & Soul

Edit Module
Edit ModuleShow Tags
Edit Module Edit ModuleShow Tags

Daily Astrology

July 23, 2019

The morning hours race by. The Aries Moon, never shy about getting a move on, is in a fire sign grand trine along with Mars and Jupiter. Anyone with a bold idea feels empowered to pursue their dream. Extraordinary mental or physical efforts are possible…
Edit ModuleShow Tags

Alternative Health Directory

Browse all listings »

Edit ModuleShow Tags
Edit ModuleShow Tags

Calendar

July 2019

The Nourished Festival brings together over 100 brands exhibiting the best specialty diet products! The Festivals have five zones to visit: Gluten-Free, Nut-Free, Paleo, Keto and Plant-Based....

Cost: $5-$15

Where:
DCU Center - North Exhibit Hall
50 Foster Street
Worcester, MA  01608
View map »


Sponsor: The Nourished Festivals; Enjoy Life Foods
Telephone: 847-284-9997
Contact Name: Laura
Website »

More information

Facilitator: Peyton Pugmire Sundays, 7/21, 8/25, 1pm-4pm Get down, boogie woogie, and paint! Join the gang for this instruction-free painting experience, including non-stop disco...

Cost: $35 (includes 1 mimosa!)

Where:
Creative Spirit
80 Washington Street
Marblehead, MA  01945
View map »


Telephone: 781-797-0389
Contact Name: Creative Spirit
Website »

More information

Join us for a Reiki Share in the Usui Reiki system of natural healing. We are a gathering of Reiki practitioners who share experiences, practice Reiki and support one other. If you...

Cost: Free

Where:
Northeast Reiki Center
61 Nicholas Road, Suite B2
Framingham, MA  01701
View map »


Sponsor: Northeast Reiki Center
Telephone: 508-808-5696
Contact Name: Lou Orsan
Website »

More information

Show More...
Show Less...

Live life to the fullest. Let go of the past and move forward making the most out of every moment! Talk, meditation, Q & A with special guest speaker Charlie Hogg Charlie is the...

Cost: Free

Where:
At Harvard Law School
Austin Hall
1585 Mass Avenue
Cambridge, MA  02138
View map »


Sponsor: Inner Space Meditation Center & Gallery
Telephone: 617-547-1110
Website »

More information

July 22–August 2 This unique program offers children a deeper awareness of who they are and how to nurture their heart and spirit while having fun. Ages 5-10, July 22-26. Ages 11-16, Jul...

Where:
Unity of Greater Portland
54 River Rd
Windham, ME  04062
View map »


Sponsor: Dancing Jaguar
Telephone: (207) 680-6942
Website »

More information

Show More...
Show Less...

Be sure to register early as this popular class typically sells out!   Gene Ang, PhD bent this twisted fork using new quantum healing techniques which clearly proved to him the ability of...

Cost: $55

Where:
Circles of Wisdom
386 Merrimack Street, Suite 1-A
Methuen, MA  01844
View map »


Sponsor: Circles of Wisdom
Telephone: 978-474-8010
Contact Name: Cathy Kneeland
Website »

More information

Show More...
Show Less...

July 24–25 This divine healing method is a set of new healing tools and cosmic energies inspired by higher beings from the star system Arcturus. It is divinely guided through the form...

Cost: $375

Where:
Circles of Wisdom
386 Merrimack Street, Suite 1-A
Methuen, MA  01844
View map »


Sponsor: Circles of Wisdom
Telephone: 978-474-8010
Contact Name: Cathy Kneeland
Website »

More information

Please join us for an evening dedicated to some of the most important issues one faces when going through divorce or separation, as well as afterwards. Attorney Jennifer Hawthorne will walk you...

Cost: Free

Where:
Skylark Law & Mediation, PC
9 Main Street
Southborough, MA  01772
View map »


Sponsor: Vesta: Redefining Divorce
Telephone: 508-744-6014
Contact Name: Deanna Coyle
Website »

More information

Free summer outdoor yoga sponsored by Mass Development and Dragonfly Wellness Center. Every Wednesday night through August 28th!   Participants must register below and bring a signed...

Cost: Free

Where:
Rogers Field
Devens, MA  01432


Sponsor: Yoga Anita
Telephone: 978-227-8297
Website »

More information

Show More...
Show Less...

Psychic Spa Summer Tune Up Night! Come detox, relax and renew yourself for the lazy summer days in our sanctuary! We have an intimate gathering of great readers and healers providing...

Cost: Special 3-15 min. sessions - $60, 15 min. session - $25

Where:
Healing Power Of Flowers—Heaven and Earth
68 Stiles Rd
Suite A
Salem, NH  03079
View map »


Sponsor: Healing Power Of Flowers - Heaven and Earth
Telephone: 603-275-7688
Contact Name: Stacey Smith
Website »

More information

The end of any relationship, particularly by divorce, brings about many changes and emotional reactions. Join us for an important workshop led by Susan Trotter, Ph.D. to discuss the common...

Cost: Free

Where:
Kellem Mahoney Family Law & Mediation Group
100 Recreation Park Drive
Suite 201
Hingham, MA  02043
View map »


Sponsor: Vesta: Redefining Divorce
Telephone: 508-744-6014
Contact Name: Deanna Coyle
Website »

More information

Show More...
Show Less...
No Events

Please join us for a day of deep healing and transformation using Holotropic Breathwork. “Consciousness does not just passively reflect the objective material world; it plays an...

Cost: $150 until April 20th, $175 after July 25th

Where:
First Congregational Church
43 Silver Street
Greenfield, MA  01301
View map »


Sponsor: Allen Howell, M.Ed. LMHC and Ellen Wolfe, MS HTR
Contact Name: Allen Howell
Website »

More information

Dealers, exhibits, lectures, demonstrations, children's activities, silent auctions, door prizes, refreshments, free parking. Handicapped accessible.

Cost: $4 adults (16-59), $3 seniors (60+), children under 16 free with paying adult

Where:
Champlain Valley Exposition
105 Pearl Street
Essex Junction, VT  05452
View map »


Sponsor: Burlington Gem and Mineral Club
Contact Name: Christine Smart
Website »

More information

Welcome to Wild Vibes! Come celebrate all the wild, and join us for the ultimate day of creativity and community at the sixth annual Wild Vibes Festival! Celebrated as New England's favorite...

Cost: $79–$149, kids ages 12 and under are free.

Where:
Spring Hill Farm
117 Pond Rd
South Berwick, ME  03908
View map »


Sponsor: Wild Vibes Fest
Telephone: 603-918-0069
Contact Name: Magnolia Campbell
Website »

More information

Guide: Lindsey Melancon JourneyDance™ is a powerful movement class that will take each participant through an inward journey using a blend of many disciplines including shamanic...

Cost: $27

Where:
Creative Spirit
80 Washington Street
Marblehead, MA  01945
View map »


Telephone: 781-797-0389
Contact Name: Creative Spirit
Website »

More information

Saturday, July 27 and Sunday, July 28, 10:30am–4:30pm A Weekend Devoted to Renewing Appreciation for Your Body You are invited to join Jennifer Kreatsoulas, PhD, certified yoga...

Cost: Early Registration $295 by June 27 ($325 thereafter)

Where:
Yogalife Institute of NH
6 Chestnut Street
Exeter, NH  03833
View map »


Sponsor: YogaLife Institute of NH
Telephone: 603-867-3969
Contact Name: Alice Bentley
Website »

More information

Medical Intuitive Remote Healing with Sue & Aaron Singleton This powerful distant healing session is available to people all over the world! You don't need to be a private student or...

Cost: $35

Where:
Everywhere/Remote
, MA


Sponsor: The Way To Balance, LLC Center for Advanced Healing & Training
Telephone: 978-834-0341
Contact Name: Veronica
Website »

More information

With Sue & Aaron Singleton Coughing, sneezing, runny nose, itchy eyes, constant mucous drainage, etc. are all signs that you may have seasonal allergies. What time of the year do your...

Cost: $35

Where:
Everywhere/Remote
, MA


Sponsor: The Way To Balance, LLC Center for Advanced Healing & Training
Telephone: 978-834-0341
Contact Name: Veronica
Website »

More information

The Eclectic Institute of Aromatherapy and Herbal Studies offers a comprehensive hands-on training in the art and science of Aromatherapy This course covers the...

Cost: $550

Where:
Windlewisp
665 Depot St
North Harwich, MA  02645
View map »


Sponsor: The Eclectic Institute of Aromatherapy and Herbal Studies
Telephone: 774-232-1721
Contact Name: Linda Patterson
Website »

More information

Show More...
Show Less...
Edit ModuleShow Tags
Edit Module Edit ModuleShow Tags