Declining Memory And Learning Deficits Linked To Canola Oil


Published:

After the public health scare in the 1970s over animal fats, sales of vegetable oils of all types increased. It was the established wisdom that those oils high in polyunsaturated fatty acids were especially beneficial. However, more research into vegetable oils continues to surface showing their damaging effects on health. A new study published online in the journal Scientific Reports shows that consumption of canola oil in the diet worsened memory, worsened learning ability and caused weight gain.

The obsession with polyunsaturated versus saturated fats led researchers and nutritionists to overlook some of the other features of vegetable oils that we now know are crucial to health, including:

  • Susceptibility to rancidity;
  • Ratio of omega-3 to omega-6 fatty acids and its relevance in inflammatory diseases and immune system function;
  • Possible presence of irritating or toxic compounds in particular plant oils.

Canola oil is one of the most widely consumed vegetable oils in the world, yet surprisingly little is known about its effects on health. In the journal Scientific Reports, researchers at the Lewis Katz School of Medicine at Temple University (LKSOM) associate the consumption of canola oil in the diet with worsened memory, worsened learning ability and weight gain in mice which models Alzheimer’s disease. The study is the first to suggest that canola oil is more harmful than healthful for the brain.

Canola oil contains a long-chain fatty acid called erucic acid, which is especially irritating to mucous membranes. Canola oil consumption has been correlated with development of fibrotic lesions of the heart, CNS degenerative disorders, lung and prostate cancer, anemia, and constipation.

Not only are canola, soybean and corn oil now coming from genetically modified crops, but their processing is beyond toxic to human metabolism.

“Canola oil is appealing because it is less expensive than other vegetable oils, and it is advertised as being healthy,” explained Domenico Pratico, MD, professor in the departments of pharmacology and microbiology and director of the Alzheimer's Center at LKSOM, as well as senior investigator on the study. “Very few studies, however, have examined that claim, especially in terms of the brain.”

Curious about how canola oil affects brain function, Dr. Pratico and Elisabetta Lauretti, a graduate student in Dr. Pratico’s laboratory at LKSOM and co-author on the new study, focused their work on memory impairment and the formation of amyloid plaques and neurofibrillary tangles in an Alzheimer’s disease mouse model. Amyloid plaques and phosphorylated tau, which is responsible for the formation of tau neurofibrillary tangles, contribute to neuronal dysfunction and degeneration and memory loss in Alzheimer’s disease. The animal model was designed to recapitulate Alzheimer’s in humans, progressing from an asymptomatic phase in early life to full-blown disease in aged animals.

Dr. Pratico and Lauretti had previously used the same mouse model in an investigation of olive oil, the results of which were published earlier in 2017. In that study, they found that Alzheimer mice fed a diet enriched with extra-virgin olive oil had reduced levels of amyloid plaques and phosphorylated tau and experienced memory improvement. For their latest work, they wanted to determine whether canola oil is similarly beneficial for the brain.

The researchers started by dividing the mice into two groups at six months of age, before the animals developed signs of Alzheimer’s disease. One group was fed a normal diet, while the other was fed a diet supplemented with the equivalent of about two tablespoons of canola oil daily.

The researchers then assessed the animals at 12 months. One of the first differences observed was in body weight -- animals on the canola oil-enriched diet weighed significantly more than mice on the regular diet. Maze tests to assess working memory, short-term memory, and learning ability uncovered additional differences. Most significantly, mice that had consumed canola oil over a period of six months suffered impairments in working memory.

Examination of brain tissue from the two groups of mice revealed that canola oil-treated animals had greatly reduced levels of amyloid beta 1-40. Amyloid beta 1-40 is the more soluble form of the amyloid beta proteins. It generally is considered to serve a beneficial role in the brain and acts as a buffer for the more harmful insoluble form, amyloid beta 1-42.

As a result of decreased amyloid beta 1-40, animals on the canola oil diet further showed increased formation of amyloid plaques in the brain, with neurons engulfed in amyloid beta 1-42. The damage was accompanied by a significant decrease in the number of contacts between neurons, indicative of extensive synapse injury. Synapses, the areas where neurons come into contact with one another, play a central role in memory formation and retrieval.

“Amyloid beta 1-40 neutralizes the actions of amyloid 1-42, which means that a decrease in 1-40, like the one observed in our study, leaves 1-42 unchecked,” Dr. Pratico explained. “In our model, this change in ratio resulted in considerable neuronal damage, decreased neural contacts, and memory impairment.”

The findings suggest that long-term consumption of canola oil is not beneficial to brain health. “Even though canola oil is a vegetable oil, we need to be careful before we say that it is healthy,” Dr. Pratico said. “Based on the evidence from this study, canola oil should not be thought of as being equivalent to oils with proven health benefits.”

The next step is to carry out a study of shorter duration to determine the minimum extent of exposure necessary to produce observable changes in the ratio of amyloid beta 1-42 to 1-40 in the brain and alter synapse connections. A longer study may be warranted in order to determine whether canola oil also eventually impacts phosphorylation, since no effects on tau were observed over the six-month exposure period.

“We also want to know whether the negative effects of canola oil are specific for Alzheimer’s disease,” Dr. Pratico added. “There is a chance that the consumption of canola oil could also affect the onset and course of other neurodegenerative diseases or other forms of dementia.”

This article was republished from Prevent Disease.

See also:
7 Reasons To Avoid GMOs And 4 Ways To Spot Them
Top 10 Nutrition Myths

Edit Module
Edit ModuleShow Tags
Edit Module Edit ModuleShow Tags

Daily Astrology

October 19, 2018

The Moon is in egalitarian Aquarius as the day begins. The early morning hours are well suited for visionary thinking and planning. However, keep an eye on expenses. By the start of most business hours a void of course Moon period has begun…
Edit ModuleShow Tags

Alternative Health Directory

Browse all listings »

Edit ModuleShow Tags
Edit ModuleShow Tags

Calendar

October 2018

October 14 - 18 Join the acclaimed Grandmaster William C. C. Chen for an intensive five-day Tai Chi Chuan Fall Retreat. Knowledge of the Yang-style short form is a requirement for participation....

Cost: Please see our website

Where:
Eastover Estate & Eco Village
430 East St.
Lenox, MA  01240
View map »


Telephone: 866-264-5139
Website »

More information

October 14 - November 19 60 PDAs A 36 day retreat in which acclaimed Qigong master, Junfeng Li, will meditate and practice not only Sheng Zhen Gong daily, but will also share traditions that...

Cost: Please see our website

Where:
Eastover Estate & Eco Village
430 East St.
Lenox, MA  01240
View map »


Telephone: 866-264-5139
Contact Name: Yingxing Wang
Website »

More information

Lunare is open to magickal vendors and holistic practitioners wishing to offer their spiritual goods and services to an audience interested in all things mystical. General admission to...

Cost: Free general admission, lecture tickets $15

Where:
Hunt Memorial Building
6 Main St
Nashua, NH  03064
View map »


Sponsor: Lunare Mystics
Telephone: 603-801-2113
Contact Name: Alyssa O'Mara
Website »

More information

Show More...
Show Less...

Join Psychic Medium Diane Lewis for gallery style readings. Diane will be connecting to spirit delivering messages from those who have crossed over. Don't miss this free event sponsored by...

Cost: Free

Where:
Hopkinton Public Library
13 Main Street
Hopkinton, MA, MA  01748
View map »


Sponsor: Hopkinton Public Library
Telephone: 617-645-6415
Contact Name: Diane Lewis
Website »

More information

Break emotional patterns that keep you stuck in the pain of addictive habits. Heal mental trauma through physical practices involving movement, breath, and meditation.

Where:
Yoga at the Ashram
368 Village Street
Millis, MA  02054
View map »


Sponsor: Yoga At The Ashram
Telephone: (508) 376-4525
Website »

More information

Show More...
Show Less...
No Events

The class is a combination of qi gong, yoga, meditation, and relaxation followed by a cup of healing tea. The class, developed by Korean enlightened master Ilchi Lee, is based on Sundo, a...

Cost: $10

Where:
Divine Paradigm
58b Macy St
Amesbury, MA  01913
View map »


Contact Name: Brad Fanger

More information

With Carrie Rowan Wednesday evenings at 7pm, a 4-week introductory class that teaches quick energy medicine tools, mini meditations to help moms/dads and caregivers reduce stress and stay calm...

Where:
Fitzgerald Institute
Northboro, MA


Telephone: (508) 273-2610
Website »

More information

Show More...
Show Less...

October 18 - 21 Magnetic-harmonic vibrational therapist, Jay Emmanuel, A.K., N.S.,V.M. shares powerful energy techniques that use the forces of sounds produced by the human voice in combination...

Cost: Please see our website

Where:
Eastover Estate & Retreat Center
430 East St.
Lenox, MA  01240
View map »


Telephone: 866-264-5139
Contact Name: Yingxing Wang
Website »

More information

Course participant experiences:  “After this course, I learned how to recognize where I hold my tension and release it.”  “My favorite part of the program is the...

Cost: $650

Where:
CHA Center for Mindfulness & Compassion
26 Central Street
2nd Floor Community Room
Somerville, MA  02143
View map »


Sponsor: CHA Center for Mindfulness & Compassion
Telephone: 617-591-6132
Contact Name: Bridget Kiley
Website »

More information

The H.E.A.R.T. Program® (Health Empowerment and Real Transformation) is an innovative holistic curriculum addressing the current health crisis and epidemics of obesity, heart disease, and...

Cost: Free

Where:
Wilbraham Senior Center
45 Post Office Park, #4502
Wilbraham, MA  01095
View map »


Sponsor: Harmony Way
Telephone: 413-636-2475
Contact Name: Michelle Caron
Website »

More information

Daily practice for peace, healing, Christ mindedness, meditation, awakening.

Where:
Milton, MA


Telephone: 617-696-5685
Website »

More information

Show More...
Show Less...

14 CEU Credits for Massage/Bodywork Therapists! Oct 19-21: Chi Nei Tsang And...pre-weekend women only event: Oct 18: Women’s Sexual Ecstacy - 1-6pm/6CEUs Chi Nei...

Cost: Please see our website

Where:
Eastover Estate & Eco Village
430 East St.
Lenox, MA  01240
View map »


Telephone: 866-264-5139
Contact Name: Yingxing Wang
Website »

More information

October 19 - 20 (Workshop runs 10-5 both days) When the phase of the Sixth Sun began with the eclipse of July 11, 2010 it was time, according to Sergio’s teacher, for the ancient...

Where:
Natick Mariott Courtyard
Natick, MA


Contact Name: Sandy Corcoran
Website »

More information

With Yogi Amandeep Adi Shakti represents all divine energies. When activated, she manifests herself as creativity, prosperity, wisdom. Rare workshop uniting ancient science of Kundalini...

Where:
Yoga at the Ashram
368 Village St
Millis, MA  02054
View map »


Telephone: (508) 376-4525
Website »

More information

Connect with the ancient wisdom of yoga. Learn how yoga practices are designed to address life’s problems, such as work stress, relationship difficulties, and common mental health issues. Be...

Cost: $40

Where:
Yogalife Institute of NH
6 Chestnut Street
Lower Level
Exeter, NH  03833
View map »


Sponsor: YogaLife Institute of NH
Telephone: 603-867-3969
Contact Name: Alice Bentley
Website »

More information

No previous experience is required for this Friday evening event. It is essential for students who are unfamiliar with using the Pathway Prayer Process© and who plan to attend the 2-day...

Cost: $35

Where:
Circles of Wisdom - New location late Summer '18
386 Merrimack Street
Methuen, MA  01844
View map »


Sponsor: Circles of Wisdom
Telephone: 978-474-8010
Contact Name: Cathy Kneeland
Website »

More information

Bee Kind Music Class with Carrie Rowan inspires a love to music in little ones. 10am on Fridays for 8 weeks at Playtown Express in Southboro. To register call (508) 480-0022 or...

Where:
Playtown Express
150 Cordaville Road
Southboro, MA
View map »


Telephone: 508-273-2610
Website »

More information

The class is a combination of qi gong, yoga, meditation, and relaxation followed by a cup of healing tea. The class, developed by Korean enlightened master Ilchi Lee, is based on Sundo, a...

Cost: $10

Where:
Divine Paradigm
58b Macy St
Amesbury, MA  01913
View map »


Contact Name: Brad Fanger

More information

“For breath is life, and if you breathe well you will live long on earth.” — Sanskrit Proverb Join us for an evening of deep exploration and transformation using the healing...

Cost: $40 (limited hardship rates available)

Where:
Museum of Modern Renaissance
115 College Avenue
Somerville, MA  02144
View map »


Sponsor: HolotropicMA
Contact Name: Allen Howell M.Ed. LMHC
Website »

More information

Show More...
Show Less...

Refresh, refocus, simplify. Discover easy tools and strategies to prepare for an incredible holiday season. 8:00–8:30 Registration open 8:30–8:35 Welcome 8:35–9:20 Circle...

Cost: $99

Where:
Women’s Health Resource Center
9 Hanover Street
Lebanon, NH  03766
View map »


Sponsor: Almstrom Financial, Green Mt. Hypnosis, Patti Friedman, Eva Loomis
Telephone: (603) 650-2600
Contact Name: Women’s Health Resource Center

More information

October 20 - 21 Early Bird Special! Register before September 30 and save $45! Prerequisite: Be familiar with accessing the Akashic Records through the Pathway Prayer Process© either...

Cost: $350 before September 30

Where:
Circles of Wisdom - New location late Summer '18
386 Merrimack Street
Methuen, MA  01844
View map »


Sponsor: Circles of Wisdom
Telephone: 978-474-8010
Contact Name: Cathy Kneeland
Website »

More information

See all that is new at Dragonfly! Come and meet our new practitioners and teachers and learn about the innovative holistic modalities that are being offered. Participate in free classes, see...

Where:
Dragonfly Wellness Center
176 Jackson Rd.
Devens, MA  MA
View map »


Telephone: 978-487-7181
Website »

More information

October 20 & 21, 10:30am-6:30pm Practices and Approaches for PTSD, Depression and Anxiety with Erin Byron, MA, E-RYT500, C-IAYT, YACEP, Licensed Mental Health Professional Experiment with...

Cost: $325

Where:
YogaLife Institute of NH
6 Chestnut Street
Exeter, NH  03833
View map »


Sponsor: YogaLife Institute of NH
Telephone: 603-867-3969
Contact Name: Alice Bentley
Website »

More information

The shamanic rattle is a sacred tool that can be used to shift into an altered state of consciousness, sense and track energy, and heal the energetic body, which contains the codes underlying...

Cost: $40

Where:
Akasha Studio
20 Birch Street
Roslindale, MA  02131
View map »


Sponsor: Miriam Katz, Shamanic Healer
Telephone: 617-545-5142
Contact Name: Miriam Katz
Website »

More information

Show More...
Show Less...
Edit ModuleShow Tags
Edit Module Edit ModuleShow Tags