Don’t Hate Your Gut: It May Help You Lose Weight, Fight Depression And Lower Blood Pressure


Published:

A universe of organisms living inside you may affect every part of your body, from your brain to your bones, and even your thoughts, feelings and your attempts to lose weight.

This is a universe of trillions of microorganisms – or what we biologists call microbiota – that live in your gut, the part of your body responsible for digestion of the food you eat and the liquids you drink.

As researchers, we have been looking increasingly into the effect these bacteria have on their host’s body, from obesity to mental illness and heart disease. With obesity, for example, these tiny organisms may play a big role by influencing what foods we crave and how our bodies hold onto fat.

In a recent study of the gut microbiome, we set out to determine whether the microbiota in the gut can be affected not only by our nervous system but also by an unsuspected source – our bone marrow.

Our hope is that, by understanding the interactions of the microbiome with other parts of the body, one day treatments could be developed for a range of illnesses.

The Gut-Brain-Bone Marrow Connection

The gut, which includes your esophagus, stomach, small and large intestines, colon and other parts of your digestive system, is the first line of defense and the largest interface between the host – in this case, a person – and the outside world.

After birth, the gut is the first point of entry for environmental and dietary influences on human life. Thus, the microbiota in the gut play a crucial role during human growth, as they contribute to development and maintenance of our immune system throughout our lifetime.

While we initially thought of the microbiota as relatively simple organisms, the fact is that they may not be so simple after all. Gut microbiota can be as personal and complex as a fingerprint.

There are more bacteria in your gut alone than cells in your entire body. This vast bacterial universe contains species that combined can have up to 150 times more genes than exist in humans. Research suggests that the bacteria in our gut predates the appearance of humans and that they may have played an important role in evolutionary separation between our ape ancestors and us.

Healthy bacteria actively interact with the host immune system in the gut. They contribute to the barrier between disease-causing microorganisms or infections introduced via ingestion. They also help prepare the host immune system to defend the body. The wrong mix of microbes, on the other hand, can contribute to many digestive, immune and mental health disorders and even obesity.

These tiny organisms work very hard in digestion. They help digest our food and can release nutrients and vitamins essential for our well being, all in exchange for the privilege of existing in a nutritious environment.

Researchers are actively exploring the many facets of this symbiotic relationship. Recent data show a link between gut microbiota diversity and richness and the way we store fat, how we regulate digestion hormones and blood glucose levels, and even what types of food we prefer.

This may also be a reason our eating habits are so difficult to change. Some research suggests that microbiota may generate cravings for foods they specialize in – even chocolate – or those that will allow them to better compete for resources against other bacteria.

A Three-Way Call?

There’s growing evidence of a link between the brain and our microbiota as well. The brain is the equivalent of a computer’s main processor, regulating all physiological variables, including the immune system, the body’s defense against infection and illness.

All immune cells are “born” in the bone marrow. From our previous research, we knew that increased bone marrow inflammation, one of many consequences of high blood pressure, was driven by a direct message from the brain. The gut, too, plays an important role in preparing the immune system for battle.

So we wondered: Could the bone marrow immune cells be playing a role in signaling between the brain and the gut? We wanted to find out.

Using a novel experimental mouse model, we replaced the bone marrow that occurs naturally within a mouse with bone marrow cells from a different, genetically modified mouse. This replacement marrow was deficient in a specific molecule called adrenergic receptor beta, which made the bone marrow less responsive to the neural messages from the brain.

In this way we could investigate how the host brain-immune communication will modify gut microbiota.

Indeed, by studying this new mouse model, we determined that our nervous system – directed by our brain – can modify the composition of gut microbiota by communicating directly with the bone marrow immune cells. The brain, therefore, can change our gut microbiota indirectly by talking to the bone.

Fewer Inflammatory Cells In Bone Marrow Resulted In Fewer In The Gut

Based on our experiments, we observed that fewer inflammatory cells were present in the circulation of mice that received the special bone marrow replacement than in those that didn’t. This means there are fewer immune cells able to infiltrate the gut and influence the bacterial environment.

Thus, by suppressing the communication between the brain and the bone marrow, we observed a muted inflammatory response in the gut and a consequent shift toward a “healthier,” more diverse microbiome.

This appears to be mediated via specific changes in inflammatory genes in the gut. However, this interaction between the host and the gut microbiota is very complex, and much more research is needed to pinpoint the exact mechanisms of their close communication.

This may also be protective against weight gain, due to the very important role that both microbiota and the immune system play in obesity.

A Key To Heart Health, Mental Health And Weight Loss?

This finding may also have implications in immune diseases as well as treatments either resulting in or employing immunosuppression. The latter may affect the gut microbiota, which in turn may cause unwanted effects in the body, including those associated with digestive and mental health conditions.

In the context of cardiovascular disease, this muted inflammatory response appears to be beneficial, as it leads to beneficial lowering of blood pressure in our experimental mice.

Most interestingly, a link between gut microbiota and our mental health has recently become clearer. In particular, some have suggested that gut microbiota influence the stress and anxiety pathways in the brain in a way that can alter mood and behavior both positively and negatively, giving a whole new meaning to the term “gut feeling.”

This could soon lead to a new class of drugs, called psychobiotics.

Much like the “chicken and the egg” scenario, however, this complex interplay warrants further investigation to fully understand the consequences (or benefits) of perturbing one single component of the gut microbiota. This understanding is essential if we are to fully harness the power of manipulation of gut microbiota in health and disease, without negative side effects.

Dr. Chris Martyniuk is a molecular toxicologist/physiologist that studies biological responses using omics methods and biochemistry. Jasenka Zubcevic is an assistant professor at the University of Florida.

This article was republished from The Conversation.

See also:
A Kitchen Ecology Of Health Resilience
Stress, Depression And Anxiety Are All Alleviated By Probiotics

Edit Module
Edit ModuleShow Tags
Edit Module Edit ModuleShow Tags

Daily Astrology

December 11, 2018

Early birds may feel discontent. A pre-dawn lunar square with Venus can magnify unmet needs. However, moods quickly rebound. Aspirations and expectations are great as the workday begins. The waxing Aquarius Moon is harmoniously engaged with Jupiter…
Edit ModuleShow Tags

Alternative Health Directory

Browse all listings »

Edit ModuleShow Tags
Edit ModuleShow Tags

Calendar

December 2018

No Events
No Events

Join us the second Tuesday evening of the month for a Reiki Share in the Usui Reiki system of natural healing. We are a gathering of Reiki practitioners who share experiences, practice...

Cost: Free

Where:
Northeast Reiki Center
61 Nicholas Road, Suite B2
Framingham, MA  01701
View map »


Sponsor: Northeast Reiki Center
Telephone: 508-808-5696
Contact Name: Lou Orsan
Website »

More information

Show More...
Show Less...

The class is a combination of qi gong, yoga, meditation, and relaxation followed by a cup of healing tea. The class, developed by Korean enlightened master Ilchi Lee, is based on Sundo, a...

Cost: $10

Where:
Divine Paradigm
58b Macy St
Amesbury, MA  01913
View map »


Contact Name: Brad Fanger

More information

Please join us at our monthly meetings, second Wednesday each month September - June in Westboro, MA. A welcoming community working for the greater health and wellbeing of all. Contact...

Where:
Sohum Yoga and Meditation Studio
30 Lyman St
#108B
Westborough, MA
View map »

More information

Show More...
Show Less...

Journaling can be a part of your inner work and is, in fact, on the tree of contemplative practices.  Whether you are a meditator or keep a journal or neither of the above, all are welcome to...

Cost: Free

Where:
Waltham Public Library
735 Main Street
Waltham, MA  02451
View map »


Sponsor: Louise Goldstein
Telephone: 617-710-6145
Contact Name: Waltham Public Library
Website »

More information

Show More...
Show Less...
No Events

Sponsored by the Canton Spiritualist Church. Held at the Blue Hills, Canton, MA. Psychics, mediums, readings for a fee. Free healings.

Cost: Free admission

Where:
Blue Hills
Canton, MA


Sponsor: Canton Spiritualist Church
Telephone: (617) 469-2568

More information

Discover the power of body tapping and nature based solutions that will help you: More effectively manage and ease chronic pain issues. Clear stuck energy with body tapping. Learn the basic...

Cost: $49

Where:
Clearpoint Center
259 East Street
Stafford Springs, CT  06076
View map »


Sponsor: Clearpoint Center
Telephone: 860-684-3994
Contact Name: Steve Munn
Website »

More information

With Susie Masters We warmly invite you to join us for The Winter Solstice Workshop. Celebrate the shortest day while giving yourself the space to feel and experience the now. During this...

Cost: $45

Where:
State of Grace Yoga and Wellness Center
104 East. Hartford Ave.
Uxbridge, MA  01569
View map »


Telephone: 508-278-2818
Website »

More information

All are invited to a special barefoot, free style dance and live music event on December 15th from 7:30pm–10pm in Greenfield, Massachusetts. We will be having a special freestyle, barefoot...

Cost: $5-$10

Where:
The Episcopal Church of St. James & Andrew
71 Federal St.
Greenfield, MA  01301
View map »


Sponsor: Dance Spree
Telephone: (413)658-7011 (no texting please)
Contact Name: Jasper Lapienski
Website »

More information

Tired of missing opportunities that could further your life, your education, even your work? Tired of missing threats that continue to hold back your life, your education, even your work? Sit down...

Cost: $40

Where:
Caffe Nero
368 Congress St
Boston, MA  02210
View map »


Contact Name: Soni
Website »

More information

Show More...
Show Less...
Edit ModuleShow Tags
Edit Module Edit ModuleShow Tags