Time-Restricted Eating Can Overcome The Bad Effects Of Faulty Genes And Unhealthy Diet


Published:

Timing our meals can fend off diseases caused by bad genes or bad diet. Everything in our body is programmed to run on a 24-hour or circadian time table that repeats every day. Nearly a dozen different genes work together to produce this 24-hour circadian cycle. These clocks are present in all of our organs, tissues and even in every cell. These internal clocks tell us when to sleep, eat, be physically active and fight diseases. As long as this internal timing system works well and we obey it, we stay healthy.

But what happens when our clocks are broken or begin to malfunction?

Mice that lack critical clock genes are clueless about when to do their daily tasks; they eat randomly during day and night and succumb to obesity, metabolic disease, chronic inflammation and many more diseases.

Even in humans, genetic studies point to several gene mutations that compromise our circadian clocks and make us prone to an array of diseases from obesity to cancer. When these faulty clock genes are combined with an unhealthy diet, the risks and severity of these diseases skyrocket.

My lab studies how circadian clocks work and how they readjust when we fly from one time zone to another or when we switch between day and night shift. We knew that the first meal of the day synchronizes our circadian clock to our daily routine. So, we wanted to learn more about timing of meals and the implications for health.

Time-Restricted Eating

A few years ago we made a surprising discovery that when mice are allowed to eat within a consistent eight- to twelve-hour period without reducing their daily caloric intake, they remain healthy and do not succumb to diseases even when they are fed unhealthy food rich in sugar or fat.

The benefit surpasses any modern medicine. Such an eating pattern – popularly called time restricted eating – also helps overweight and obese humans reduce body weight and lower their risk for many chronic diseases.

Decades of research had taught us what and how much we eat matters. But the new discovery about when we eat raised many questions.

How does simply restricting your eating times alter so many elements of personal health? The timing of eating is like an external time cue that signals the internal circadian clock to keep a balance between nourishment and repair. During the eating period, metabolism was geared toward nourishment. The gut and liver better absorbed nutrients from food, and used some for fueling the body while storing the rest.

During the fasting period, metabolism switched to rejuvenation. Unwanted chemicals were broken down, stored fat was burned and damaged cells were repaired. The next day, after the first bite, the switch flipped from rejuvenation to nourishment. This rhythm continued every day. We thought that timing of eating and fasting was giving cues to the internal clock and the clock was flipping the switch between nourishment and rejuvenation every day. However, it was not clear if a normal circadian clock was necessary to mediate the benefits of time restricted eating or whether just restricted eating times alone could flip the daily switch.

What If You Have A Broken Internal Clock?

In a new study, we took genetically engineered animals that lacked a functioning circadian clock either in the liver or in every cell of the body.

These mice, with faulty clocks don’t know when to eat and when to stay away from food. So, they eat randomly and develop multiple diseases. The disease severity increases if they are fed an unhealthy diet.

To test if time restricted eating works with a damaged or dysfunctional clock, we simply divided these mutant mice into two different groups – one group got to eat whenever they wanted and the other group was only given access to food during restricted times. Both groups ate the identical number of calories, but the restricted eaters finished their daily ration within nine to 10 hours.

We thought that even though these mice had restricted eating times, having the bad clock gene would doom them to obesity and many metabolic diseases. But to our utter surprise the restricted eating times trumped the bad effects of faulty clock genes. The mice without a functioning clock that were destined to be morbidly sick, were as healthy as normal mice when they consumed food during a certain period.

The results have many implications for human health.

The Good News

First of all, it raises a big question: What is the connection between our genetically encoded circadian clock timing system and external time of eating? Do these two different timing systems work together like co-pilots in a plane, so that even if one is incapacitated, the other one can still fly the plane?

Deep analyses of mice in our experiment revealed that time restricted eating triggers many internal programs that improve our body’s resilience – enabling us to fight off any unhealthy consequences of bad nutrition or any other stress. This boost in internal resilience may be the key to these surprising health benefits.

For human health the message is simple, as I say in my new book “The Circadian Code.” Even if we have faulty circadian genes as in many congenital diseases, such as Prader-Willi syndrome or Smith-Magenis syndrome, or carry a malfunctioning copy of nearly a dozen different clock genes, as long as we have some discipline and restrict eating times, we can still fend off the bad effects of bad genes.

Similarly, other researchers have shown as we get older our circadian clock system weakens. The genes don’t function correctly so our sleep-wake cycles are disrupted – just as if we had a faulty clock. So, lifestyle becomes more important for older people who are at higher risk for many chronic diseases such as diabetes, heart disease, high cholesterol, fatty liver disease and cancer.

As a potential translation to human health, we have created a website where anyone from anywhere in the world can sign up for an academic study and download a free app called MyCircadianClock and start self-monitoring the timing of eating and sleeping.

The app provides tips and guidance on how to adopt a time restricted eating lifestyle to improve health and prevent or manage chronic diseases. By collecting data from people with varying risk for disease, we can explore how eating times can help to increase our healthy lifespan.

We understand everyone’s lifestyle around home, work and other responsibilities is unique and one size may not fit all. So, we hope people can use the app and some tips to build their personalized circadian routine. By selecting their own time window of eight to twelve hours for eating that best fits their lifestyle, they may reap many health benefits.The Conversation

Satchin Panda, a professor in the Regulatory Biology Laboratory, is interested in understanding the molecular mechanism of the biological clock in a mouse model system. The biological clock or circadian oscillator in most organisms coordinates behavior and physiology with the natural light-dark cycle. His laboratory uses genetic, genomics and biochemical approaches to identify genes under circadian regulation in different organs and to understand the mechanism of such regulation.

This article is republished from The Conversation under a Creative Commons license. Read the original article.

See also:
How Plant-Based Diets Can Heal Our Bodies And The Planet
Overeating? It May Be A Brain Glitch

Edit Module
Edit ModuleShow Tags
Edit Module Edit ModuleShow Tags

Daily Astrology

November 18, 2018

It’s a delightfully lazy Sunday morning. The Moon is void of course in Pisces. Sleep late. Relax. Indulge in sentimental favorites, comfort foods, familiar songs, faces and places. Enjoy mother nature. By late morning the Moon enters “get up and go”…
Edit ModuleShow Tags

Alternative Health Directory

Browse all listings »

Edit ModuleShow Tags
Edit ModuleShow Tags

Calendar

November 2018

Join us and take your intuitive skills to the next level! The goal of this series is to create a sanctuary of learning and support where all can deepen their connection to spirit, stretch...

Cost: $45

Where:
Private Office
6 Royal Crest Drive
Apt 11
North Andover, MA  01845
View map »


Sponsor: Sacred Spiral Dance
Telephone: 978-973-6637
Contact Name: Diana Harris
Website »

More information

Celebrate and give thanks for harvest of the summers effort! We have a fun line up of readers and healers providing services at sampler rates to enjoy their services while you enjoy shopping...

Cost: $60—3 15 min. sessions (45 min total), $25—15 min. session

Where:
The Healing Power of Flowers—Heaven and Earth
68 Stiles Rd
Unit A
Salem, MA  03079
View map »


Sponsor: The Healing Power of Flowers—Heavven and Earth
Telephone: 603-275-7688
Contact Name: Stacey Smith
Website »

More information

Where do they go? A chat about what happens when a person passes. Where do they go? This is a question psychic medium Diane Lewis has been asked over and over again. Many of us wonder,...

Cost: Free

Where:
Together We Can New England
148 Thompson Road
Webster, MA, MA  01570
View map »


Sponsor: Together We Can New England
Telephone: 508-943-1637
Contact Name: Caryl
Website »

More information

Kinetic Chain Release, moxibustion and past life regression at Leapin Lizards. Every third Sunday: 9/16/18 10/21/18 11/18/18 12/16/18 For information, call Leapin Lizards at (207)...

Where:
Leapin Lizards
449 Forest Ave
Portland, ME
View map »


Telephone: (207) 221-2363
Website »

More information

This three-part series attunes you as a conduit to the healing system of Kundalini Reiki, a firey earth-based feminine energy. Kundalini Reiki is a gentle yet powerful modality to channel healing...

Cost: $150

Where:
Akasha Studio
20 Birch Street
Roslindale, MA  02131
View map »


Sponsor: Miriam Katz, Shamanic Healer
Telephone: 617-545-5142
Contact Name: Miriam Katz
Website »

More information

Show More...
Show Less...
No Events
No Events

The class is a combination of qi gong, yoga, meditation, and relaxation followed by a cup of healing tea. The class, developed by Korean enlightened master Ilchi Lee, is based on Sundo, a...

Cost: $10

Where:
Divine Paradigm
58b Macy St
Amesbury, MA  01913
View map »


Contact Name: Brad Fanger

More information

Show More...
Show Less...
No Events

The class is a combination of qi gong, yoga, meditation, and relaxation followed by a cup of healing tea. The class, developed by Korean enlightened master Ilchi Lee, is based on Sundo, a...

Cost: $10

Where:
Divine Paradigm
58b Macy St
Amesbury, MA  01913
View map »


Contact Name: Brad Fanger

More information

Show More...
Show Less...

With Katie Malloy Ramaci  Expand your connection to the angels by learning IET levels 2 and 3 certification. Truly move forward on your path. Learn Soulstar activation and release...

Cost: $1099 (Early Bird $999)

Where:
Women of Wisdom
118 Washington Street
North Easton, MA  02356
View map »


Sponsor: Women of Wisdom
Telephone: 508-230-3680
Contact Name: Women of Wisdom
Website »

More information

Join the Heart’s Desire Herd of Empowered Equines in Rochester, Massachusetts for an afternoon of peace and serenity. Remove yourself from the hustle and bustle of the holidays. Discover...

Cost: $65—some partial scholarships available

Where:
Heart’s Desire Stable
Rochester, MA  02770


Sponsor: Heart's Desire Stable
Telephone: 508-763-5254
Contact Name: Chris Korben
Website »

More information

Show More...
Show Less...
Edit ModuleShow Tags
Edit Module Edit ModuleShow Tags